Caffeine prevents exercise-induced hypoglycemia in trained runners
The objective of this study was to analyze the physiological, biochemical, and perceptive effects of caffeine intake in marathon runners after a maximal treadmill stress test. The sample comprised randomly selected 12 male athletes of long distance races (42,125 km). The participants performed the maximal stress test twice, after ingesting a placebo and caffeine (dose de 6 mg.kg-1) capsules, using double-blind methodology. Anthropometric parameters, heart rate (HR), blood pressure (BP), and subjective perception of effort (SPE) were evaluated before, during, and after the test. Blood samples for analyses of glucose, lactate (LAC), and triglyceride (TG) levels were also collected at the same time. The maximal stress test was performed on a treadmill, and parameters such as VO2 max and subjective perception of effort (SPE) were analyzed. Before the trial and caffeine/placebo ingestion, capillary blood was collected by finger puncture for subsequent analyses. Subsequently, the maximal treadmill stress test was initiated with a 3-minute low intensity warm-up phase. The trial continued with the maximal treadmill stress test protocol, followed by a cool-down period (walk) until HR normalization. The athletes remained seated for 10 minutes, and during this period, HR and BP were measured, and blood samples were collected. HR values presented no difference between groups. However, glucose, TG, and LAC levels different after caffeine intake. The results of the present study demonstrated that caffeine ingestion modifies glucose, TG, and LAC availability during exercise in trained runners.
Altermann, A.M., et al. 2012. A influência da cafeína como recurso ergogênico no exercício físico: sua ação e efeitos colaterais. RBNE-Revista Brasileira de Nutrição Esportiva, 2(10): 225-239.
American College of Sports Medicine. 2007. Diretrizes de ACSM para os testes de esforço e sua prescrição. Guanabara Koogan.
Battram, D.S., et al. 2006. The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men. The Journal of nutrition, 136(5): 1276-1280. https://doi.org/10.1093/jn/136.5.1276
Borg, G.A. 1982. Psychophysical bases of perceived exertion. Med sci sports exerc, 14(5), 377-381. https://doi.org/10.1249/00005768-198205000-00012
Boulé, N.G., et al. 2001. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. Jama, 286(10): 1218-1227. https://doi.org/10.1001/jama.286.10.1218
Canto, C., et al. 2006. Neuregulins mediate calcium-induced glucose transport during muscle contraction. Journal of Biological Chemistry, 281(31): 21690-21697. https://doi.org/10.1074/jbc.M600475200
Chu, Y.F., et al. 2011. Type 2 diabetes-related bioactivities of coffee: assessment of antioxidant activity, NF-κB inhibition, and stimulation of glucose uptake. Food chemistry, 124(3): 914-920. https://doi.org/10.1016/j.foodchem.2010.07.019
Daniels, J.W., et al. 1998. Effects of caffeine on blood pressure, heart rate, and forearm blood flow during dynamic leg exercise. Journal of Applied Physiology, 85(1): 154-159. https://doi.org/10.1152/jappl.19126.96.36.199
Doherty, M., and Smith, P.M. 2004. Effects of caffeine ingestion on exercise testing: a meta-analysis. International journal of sport nutrition and exercise metabolism, 14(6): 626-646. https://doi.org/10.1123/ijsnem.14.6.626
Egawa, T., et al. 2009. Caffeine acutely activates 5′ adenosine monophosphate–activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism, 58(11): 1609-1617. https://doi.org/10.1016/j.metabol.2009.05.013
Ferreira, A.M.D., et al. 2003. A influência da suplementação de triglicerídeos de cadeia média no desempenho em exercícios de ultra-resistência. Rev Bras Med Esporte, 9(6): 413-419. https://doi.org/10.1590/S1517-86922003000600006
Goldstein, E.R., et al. 2010. International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition, 7(1): 5. https://doi.org/10.1186/1550-2783-7-5
Graham, T.E. 2001. Caffeine and Exercise, Metabolism, Endurance and Performance. Sports Medicine. 31(11): 785-807. https://doi.org/10.2165/00007256-200131110-00002
Graham, T.E., and Spriet, L.L. 1996. Caffeine and exercise performance. Sports science exchange. Barrington, IL: Gatorade Sports Science Institute, 9(60): 1-5.
Graham, T.E., et al. 2008. Does caffeine alter muscle carbohydrate and fat metabolism during exercise?. Applied Physiology, Nutrition, and Metabolism, 33(6): 1311-1318. https://doi.org/10.1139/H08-129
Greenberg, J. A., et al. 2006. Coffee, diabetes, and weight control. The American journal of clinical nutrition, 84(4): 682-693. https://doi.org/10.1093/ajcn/84.4.682
Greer, F., et al. 2001. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes, 50(10): 2349-2354. https://doi.org/10.2337/diabetes.50.10.2349
Jackson, A.S., et al. 1988. Reliability and validity of bioelectrical impedance in determining body composition. Journal of Applied Physiology, 64(2): 529-534. https://doi.org/10.1152/jappl.19188.8.131.529
Jensen, T.E., et al. 2007. Caffeine-induced Ca 2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle. American Journal of Physiology-Endocrinology and Metabolism, 293(1): 286-292. https://doi.org/10.1152/ajpendo.00693.2006
Lindinger, M.I., et al. 1993. Caffeine attenuates the exercise-induced increase in plasma [K+] in humans. Journal of Applied Physiology, 74(3): 1149-1155. https://doi.org/10.1152/jappl.19184.108.40.2069
Long, Y.C., and Zierath, J.R. 2006. AMP-activated protein kinase signaling in metabolic regulation. Journal of Clinical Investigation, 116(7): 1776. https://doi.org/10.1172/JCI29044
Moisey, L.L., et al. 2008. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. The American journal of clinical nutrition, 87(5): 1254-1261. https://doi.org/10.1093/ajcn/87.5.1254
Mukwevho, E., et al. 2008. Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. American Journal of Physiology-Endocrinology and Metabolism, 294(3): 582-588. https://doi.org/10.1152/ajpendo.00312.2007
Nabholz, T.V. 2007. Nutrição esportiva: aspectos relacionados à suplementação nutricional. São Paulo: Sarvier.
Paluska, S. A. 2003. Caffeine and exercise. Curr Sports Med Rep, 2(4): 213-9. https://doi.org/10.1249/00149619-200308000-00008
Park, S., et al. 2007. Long-term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin-like growth factor 1 signaling in diabetic rats. Metabolism, 56(5): 599-607. https://doi.org/10.1016/j.metabol.2006.12.004
Park, S., et al. 2009. Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle. American Journal of Physiology-Cell Physiology, 296(1): 106-115. https://doi.org/10.1152/ajpcell.00114.2008
Randle, P., et al. 1964. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochemical Journal, 93(3): 652. https://doi.org/10.1042/bj0930652
Ruderman, N. B., and Saha, A. K. 2006. Metabolic Syndrome: Adenosine Monophosphate‐activated Protein Kinase and Malonyl Coenzyme A. Obesity, 14(S2): 25-33. https://doi.org/10.1038/oby.2006.279
Silveira, L. R., et al. 2008. Efeito da lipólise induzida pela cafeína na performance e no metabolismo de glicose durante o exercício intermitente. Revista Brasileira de Ciência e Movimento, 12(3): 21-26.
Siri, W.E. 1961. Body composition from fluid spaces and density: analysis of methods. Techniques for measuring body composition. 61: 223-44.
Skinner, T.L., et al. 2013. Coinciding exercise with peak serum caffeine does not improve cycling performance. Journal of science and medicine in sport, 16(1): 54-59. https://doi.org/10.1016/j.jsams.2012.04.004
Smith, A. 2002. Effects of caffeine on human behavior. Food and chemical toxicology, 40(9): 1243-1255. https://doi.org/10.1016/S0278-6915(02)00096-0
Sociedade Brasileira De Cardiologia (SBC). 2002. II Diretrizes da Sociedade Brasileira de Cardiologia sobre Teste Ergométrico. Arq Bras Cardiol. 78(supl. II): 1-17. https://doi.org/10.1590/S0066-782X2002000900001
Talanian, J.L., and Spriet, L.L. 2016. Low and moderate doses of caffeine late in exercise improve performance in trained cyclists. Applied Physiology, Nutrition, and Metabolism, 41(8): 850-855. https://doi.org/10.1139/apnm-2016-0053
Vanakoski, J., et al. 1998. Creatine and caffeine in anaerobic and aerobic exercise: effects on physical performance and pharmacokinetic considerations. International journal of clinical pharmacology and therapeutics, 36(5): 258-262.
Wilmore, J.H., and Costill, D.L. 2001. Fisiologia do esporte e do exercício. São Paulo, ed. Manole, 2: 28-51.
Wright, D.C., et al. 2004. Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes, 53(2): 330-335. https://doi.org/10.2337/diabetes.53.2.330
Yeo, S.E., et al. 2005. Caffeine increases exogenous carbohydrate oxidation during exercise. Journal of applied physiology, 99(3): 844-850. https://doi.org/10.1152/japplphysiol.00170.2005
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