Neuromuscular and metabolic responses of the pre-exhaustion method in highly-trained individuals


  • Gaspar Pinto Silva University of Lavras, Lavras, Brazil
  • Miller Pereira Guimarães Group of studies and research on neuromuscular responses (GEPREN), University of Lavras, Lavras Presbyterian College Gammon (PCG) – Departament of Physical Education - Lavras, Brazil
  • Yuri Almeida Costa Campos Group of studies and research on neuromuscular responses (GEPREN), University of Lavras, Lavras Postgraduate Stricto Sensu Program of the Faculty of Physical Education and Sports (FAEFID), University of Juiz de Fora, Juiz de Fora, Brazil
  • Osvaldo Costa Moreira Group of studies and research on neuromuscular responses (GEPREN), University of Lavras, Lavras, Brazil Institute of Biomedicine, University of León, León, Spain. Institute of Biological Science and Health, University of Viçosa, Florestal, Brazil, Brazil
  • Sandro Fernandes da Silva University of Lavras, Brazil



Resistance training, Electromyography, Methods of training, Lactate, Activation


Several studies investigated the pre-exhaustion resistance training (PERT), no study investigated the responses after the pre-fatigue of two auxiliary muscles. The purpose of this study was to evaluate the neuromuscular and metabolic effects of PERT in highly-trained individuals. Twenty-one men (24.90 ± 4.54 years) who were experienced in resistance training were randomly distributed into two groups. In the conventional resistance training (CRT), three sets of each exercise were performed separately (front raise [FR], triceps-forehead [TF] extensions, and bench press [BP]), with an interval of 45 seconds between the sets. In the PERT method, the exercises were performed in sequence (FR, TF, and BP), with an interval of 2 minutes 15 seconds between the sets. The electromyography (EMG), signal was acquired during the execution of the FR, TF, and BP exercises, and the muscles anterior deltoid, triceps brachii long head, and pectoralis major (clavicular head and sternal head). Lactate levels were measured before workout and at the end of each set in each method. There was no difference in the EMG activation of PMC and PMS muscles when compared to the PERT and CRT methods. Clavicular portion, PERT/CRT: 1st 42.1±7.1/42.1±6.6µV, 2st  45.9±5.5/43.5±6.2 µV, 3rd 45.5±5.7/43.9±6.1µV. Sternal portion, PERT/CRT: 1st 36.2±9/35±5.7µV, 2st 38.3±8.9/35.3±6µV, 3rd 36.8±7.1/35.1±5.1µV. However, lactate accumulation was significantly higher in PERT when compared CRT. PERT/CRT 1st 7.6.0±1.8/5.7±1.5 mmol.l-1; 2st: 9.5±1.5/8.4±2 mmol.l-1; 3rd:10.0±2.1/9.4±1.8 mmol.l-1, when compared to CRT. The PERT was more effective, producing greater metabolic stress, demonstrating to be a high-intensity method that leads to muscle adaptation.


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ACSM. (2009). Progression models in resistance training for healthy adults. Med Sci Sports Exerc., 41(3), 687-708.

Angleri, V., Ugrinowitsch, C., & Libardi, C. A. (2017). Crescent pyramid and drop-set systems do not promote greater strength gains, muscle hypertrophy, and changes on muscle architecture compared with traditional resistance training in well-trained men. Eur J Appl Physiol., 117(2), 359-369.

Arazi, H., Rahmati, S., Pashazadeh, F., & Rezaei, H. (2015). Comparative effect of order based resistance exercises on number of repetitions, rating of perceived exertion and muscle damage biomarkers in men. Rev Andaluza Med Deporte, 8(4), 139-144.

Artur, G., Adam, M., Przemyslaw, P., Stastny, P., James, T., & Adam, Z. (2017). Effects of pre-exhaustion on the patterns of muscular activity in the flat bench press. J Strength Cond Res., 31(7), 1919-1924.

Augustsson, J., Thomeé, R., Per, H., Perlindblom, J., Karlsson, J., & Grimby, G. (2003). Effect of pre-exhaustion exercise on lower-extremity muscle activation during a leg press exercise. J Strength Cond Res., 17(2), 411-416.

Bishop, D. (2001). Evaluation of the Accusport® lactate analyser. Int J Sports Med., 22(07), 525-530.

Brennecke, A., Guimarães, T. M., Leone, R., Cadarci, M., Mochizuki, L., Simão, R., . . . Serrão, J. C. (2009). Neuromuscular activity during bench press exercise performed with and without the preexhaustion method. J Strength Cond Res., 23(7), 1933-1940.

Brown, L. E., & Weir, J. P. (2001). Asep procedures recomendation i: Accurate assessment of muscular strength and power. J Exerc Physiol Online, 4(11), 1-21.

Campos, Y. A., Guimarães, M. P., de Souza, H. L., da Silva, G. P., Domingos, P. R., Resende, N. M., . . . Vianna, J. M. (2017). Relationship between the Anaerobic Threshold Identified Through Blood Lactate between the Discontinuous and Resisted Dynamic Exercises in Long Distance Runners. J Exerc Physiol Online, 20(1), 83-91.

Chatel, B., Bret, C., Edouard, P., Oullion, R., Freund, H., & Messonnier, L. A. (2016). Lactate recovery kinetics in response to high-intensity exercises. Eur J Appl Physiol., 116(8), 1455-1465.

Da Silva, G. P., Campos, Y. A. C., Guimarães, M. P., Calil, A., & da Silva, S. F. (2014). Estudo eletromiográfico do exercício supino executado em diferentes ângulos. Rev And Med Deporte, 7(2), 78-82.

De Souza, J. A., Paz, G. A., & Miranda, H. (2017). Blood lactate concentration and strength performance between agonist-antagonist paired set, superset and traditional set training. Arch Med Deporte, 34(3), 145-150.

Ferreira, D. V., Ferreira-Júnior, J. B., Soares, S. R., Cadore, E. L., Izquierdo, M., Brown, L. E., & Bottaro, M. (2017). Chest press exercises with different stability requirements result in similar muscle damage recovery in resistance-trained men. J Strength Cond Res., 31(1), 71-79.

Fisher, J., Carlson, L., Steele, J., & Smith, D. (2014). The effects of pre-exhaustion, exercise order, and rest intervals in a full-body resistance training intervention. Appl Physiol Nutr Metab., 39(11), 1265-1270.

Gentil, P., Oliveira, E., Júnior, V., Do Carmo, J., & Bottaro, M. (2007). Effects of exercise order on upper-body muscle activation and exercise performance. J Strength Cond Res., 21(4), 1082-1086.

Guarascio, M. J., Penn, C., & Sparks, C. (2016). Effects of Pre-Exhaustion of a Secundary Synergist on a Primary Mover in a Compound Exercise. J Exerc Sports Orthop, 3(1), 1-4.

Jackson, A. S., & Pollock, M. L. (1978). Generalized equations for predicting body density of men. British Journal of Nutrition, 40(03), 497-504.

Mangine, G. T., Hoffman, J. R., Gonzalez, A. M., Townsend, J. R., Wells, A. J., Jajtner, A. R., . . . Wang, R. (2015). The effect of training volume and intensity on improvements in muscular strength and size in resistance‐trained men. Physiol Rep, 3(8), e12472.

Merletti, R., & Di Torino, P. (1999). Standards for reporting EMG data. Journal of Electromyography and Kinesiology, 9(1), 3-4.

Proia, P., Di Liegro, C. M., Schiera, G., Fricano, A., & Di Liegro, I. (2016). Lactate as a Metabolite and a Regulator in the Central Nervous System. Int J Mol Sci 17(9), 1450.

Rauch, J. T., Ugrinowitsch, C., Barakat, C. I., Alvarez, M. R., Brummert, D. L., Aube, D. W., . . . De Souza, E. O. (2017). Auto-regulated exercise selection training regimen produces small increases in lean body mass and maximal strength adaptations in strength-trained individuals. J Strength Cond Res.

Schoenfeld, B. J., Pope, Z. K., Benik, F. M., Hester, G. M., Sellers, J., Nooner, J. L., . . . Ross, C. L. (2016). Longer interset rest periods enhance muscle strength and hypertrophy in resistance-trained men. J Strength Cond Res., 30(7), 1805-1812.

Schoenfeld, B. J., Ratamess, N. A., Peterson, M. D., Contreras, B., & Tiryaki-Sonmez, G. (2015). Influence of resistance training frequency on muscular adaptations in well-trained men. J Strength Cond Res., 29(7), 1821-1829.

Sforzo, G. A., & Touey, P. R. (1996). Manipulating Exercise Order Affects Muscular Performance During a Resistance Exercise Training Session. J Strength Cond Res., 10(1), 20-24.

Simao, R., de Salles, B. F., Figueiredo, T., Dias, I., & Willardson, J. M. (2012). Exercise order in resistance training. Sports Medicine, 42(3), 251-265.

Simão, R., Farinatti, P. d. T. V., Polito, M. D., Maior, A. S., & Fleck, S. J. (2005). Influence of exercise order on the number of repetitions performed and perceived exertion during resistance exercises. J Strength Cond Res., 19(1), 152-156.

Soares, E. G., Brown, L. E., Gomes, W. A., Corrêa, D. A., Serpa, É. P., da Silva, J. J., . . . Lopes, C. R. (2016). Comparison between Pre-Exhaustion and Traditional Exercise Order on Muscle Activation and Performance in Trained Men. J Sports Sci Med, 15(1), 111-117.

Spineti, J., De Salles, B. F., Rhea, M. R., Lavigne, D., Matta, T., Miranda, F., . . . Simão, R. (2010). Influence of exercise order on maximum strength and muscle volume in nonlinear periodized resistance training. J Strength Cond Res., 24(11), 2962-2969.

Tan, B. (1999). Manipulating Resistance Training Program Variables to Optimize Maximum Strength in Men: A Review. J Strength Cond Res., 13(3), 289-304.

Wirtz, N., Wahl, P., Kleinöder, H., & Mester, J. (2014). Lactate kinetics during multiple set resistance exercise. J Sports Sci Med, 13(1), 73-77.


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How to Cite

Silva, G. P., Guimarães, M. P., Campos, Y. A. C., Moreira, O. C., & da Silva, S. F. (2019). Neuromuscular and metabolic responses of the pre-exhaustion method in highly-trained individuals. Journal of Human Sport and Exercise, 14(1), 112–121.



Sport Medicine, Nutrition & Health

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