Effects of oral capsaicinoids and capsinoids supplementation on resistance and high intensity interval training
A systematic review of randomized controlled trials
Keywords:Sports nutrition, Sports performance, Resistance training, Human physical conditioning
Oral capsaicinoids and capsinoids supplementation has been studied recently for a plausible ergogenic impact on sports performance. However, non-aggregated literature has focused on the impact of this substances in healthy humans’ performance. The aim of the present systematic review was to explore the effects of capsaicinoids and capsinoids on resistance training (RT) and HIIT exercise. Studies searches were performed in the PubMed/MEDLINE, Scopus and Web of Science electronic databases. Studies where healthy subjects consumed capsaicinoids or capsinoids acutely or chronically compared to placebo before a RT or HIIT intervention were included. The methodological quality of the included studies was assessed with PEDro checklist. A total of 7 excellent-good quality placebo-controlled trials (i.e., 5 RT and 2 HIIT experiments) were included. The most prevalent protocol used capsaicin (i.e., 6 capsacin and 1 capsiate studies) and acute (i.e., 5 of 7 interventions) supplementation designs. Positive effects were only noted for capsaicin in repetitions until failure (+14.4 to +21.7%), total weight lifted (+13.0 to +23.3%), perceived effort (-6.4%), fatigue index (+15.0%) and peak torque (+6.1%) compared to placebo. Neuromuscular HIIT variables (e.g., total and medium sprint time) were not highly affected by capsaicin except the time to reach 90% VO2 peak (+61.2%) and the number of efforts performed (+14.7%). Collectively, our findings suggest a positive effect of 12 mg of capsaicin on strength endurance, total weight lifted and perceived effort variables in healthy males after acute (i.e., 45 minutes pre-exercise) supplementation.
Alali, M., Alqubaisy, M., Aljaafari, M. N., Alali, A. O., Baqais, L., Molouki, A., Abushelaibi, A., Lai, K. S., & Lim, S. H. E. (2021). Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules, 26(9). https://doi.org/10.3390/molecules26092540
Amann, M., Blain, G. M., Proctor, L. T., Sebranek, J. J., Pegelow, D. F., & Dempsey, J. A. (2010). Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans. Journal of Applied Physiology (Bethesda, Md. : 1985), 109(4), 966-976. https://doi.org/10.1152/japplphysiol.00462.2010
Baamonde, A., Lastra, A., Juarez, L., Hidalgo, A., & Menéndez, L. (2005). TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues. Brain Research Bulletin, 67(6), 476-481. https://doi.org/10.1016/j.brainresbull.2005.07.001
Basith, S., Cui, M., Hong, S., & Choi, S. (2016). Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules, 21(8). https://doi.org/10.3390/molecules21080966
Chrubasik, S., Weiser, T., & Beime, B. (2010). Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. Phytotherapy Research, 24(12), 1877-1885. https://doi.org/10.1002/ptr.3335
Collins, B. W., Pearcey, G. E. P., Buckle, N. C. M., Power, K. E., & Button, D. C. (2018). Neuromuscular fatigue during repeated sprint exercise: underlying physiology and methodological considerations. Applied Physiology, Nutrition, and Metabolism, 43(11), 1166-1175. https://doi.org/10.1139/apnm-2018-0080
Cross, B. L., Parker, D., Langan, S. P., & Grosicki, G. J. (2020). Effect of a commercially available low-dose capsaicin supplement on knee extensor contractile function. International Journal of Exercise Science, 13(2), 312-318.
de Freitas, M. C., Billaut, F., Panissa, V. L. G., Rossi, F. E., Figueiredo, C., Caperuto, E. C., & Lira, F. S. (2019a). Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying metabolic responses in physically active men. European Journal of Applied Physiology, 119(4), 971-979. https://doi.org/10.1007/s00421-019-04086-w
de Freitas, M. C., Cholewa, J. M., Freire, R. V., Carmo, B. A., Bottan, J., Bratfich, M., della Bandeira, M. P., Gonçalves, D. C., Caperuto, E. C., Lira, F. S., Lira, F. S., & Rossi, F. E. (2018). Acute capsaicin supplementation improves resistance training performance in trained men. Journal of Strength and Conditioning Research, 32(8), 2227-2232. https://doi.org/10.1519/jsc.0000000000002109
de Freitas, M. C., Cholewa, J. M., Panissa, V. L. G., Toloi, G. G., Netto, H. C., Zanini de Freitas, C., Freire, R. V., Lira, F. S., & Rossi, F. E. (2019). Acute Capsaicin Supplementation Improved Resistance Exercise Performance Performed After a High-Intensity Intermittent Running in Resistance-Trained Men. Journal of Strength and Conditioning Research, Publish Ah, 6-10. https://doi.org/10.1519/jsc.0000000000003431
de Moura e Silva, V. E. L., Cholewa, J. M., Billaut, F., Jäger, R., de Freitas, M. C., Lira, F. S., & Rossi, F. E. (2021a). Capsaicinoid and capsinoids as an ergogenic aid: A systematic review and the potential mechanisms involved. International Journal of Sports Physiology and Performance, 16(4), 464-473. https://doi.org/10.1123/IJSPP.2020-0677
de Moura e Silva, V. E. L., Cholewa, J. M., Jäger, R., Zanchi, N. E., de Freitas, M. C., de Moura, R. C., Barros, E. M. L., Antunes, B. M., Caperuto, E. C., Ribeiro, S. L. G., Lira, F. S., Pereira dos Santos, M. A., & Rossi, F. E. (2021). Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study. Journal of the International Society of Sports Nutrition, 18(1), 1-9. https://doi.org/10.1186/s12970-021-00446-0
Drevon, D., Fursa, S. R., & Malcolm, A. L. (2017). Intercoder Reliability and Validity of WebPlotDigitizer in Extracting Graphed Data. Behavior Modification, 41(2), 323-339. https://doi.org/10.1177/0145445516673998
Foley, N. C., Bhogal, S. K., Teasell, R. W., Bureau, Y., & Speechley, M. R. (2006). Database Scale to Assess the Methodology of Randomized Controlled Trials of. Physical Therapy, 86(6), 817-824. https://doi.org/10.1093/ptj/86.6.817
Froyd, C., Millet, G. Y., & Noakes, T. D. (2013). The development of peripheral fatigue and short-term recovery during self-paced high-intensity exercise. Journal of Physiology, 591(5), 1339-1346. https://doi.org/10.1113/jphysiol.2012.245316
Hayman, M., & Kam, P. C. A. (2008). Capsaicin: A review of its pharmacology and clinical applications. Current Anaesthesia and Critical Care, 19(5-6), 338-343. https://doi.org/10.1016/j.cacc.2008.07.003
Ito, N., Ruegg, U. T., Kudo, A., Miyagoe-Suzuki, Y., & Takeda, S. (2013). Capsaicin mimics mechanical load-induced intracellular signaling events: Involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Channels, 7(3), 221-224. https://doi.org/10.4161/chan.24583
Jes, A., Paola, L., Tobal, F. M., Jodra, P., Jos, J., Guerra-hern, E. J., Jos, J., & Ramos-, Á. (2021). Professional Rugby Players. 1-15.
Kamiński, M., Kręgielska-Narożna, M., & Bogdański, P. (2020). Determination of the popularity of dietary supplements using google search rankings. Nutrients, 12(4). https://doi.org/10.3390/nu12040908
Kaufman, M. P., Iwamoto, G. A., Longhurst, J. C., & Mitchell, J. H. (1982). Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle. Circulation Research, 50(1), 133-139. https://doi.org/10.1161/01.RES.50.1.133
Knapik, J. J., Steelman, R. A., Hoedebecke, S. S., Austin, K. G., Farina, E. K., & Lieberman, H. R. (2016). Prevalence of Dietary Supplement Use by Athletes: Systematic Review and Meta-Analysis. Sports Medicine, 46(1), 103-123. https://doi.org/10.1007/s40279-015-0387-7
Knotkova, H., Pappagallo, M., & Szallasi, A. (2008). Capsaicin (TRPV1 agonist) therapy for pain relief: Farewell or revival? Clinical Journal of Pain, 24(2), 142-154. https://doi.org/10.1097/AJP.0b013e318158ed9e
Lang, Y., Kisaka, H., Sugiyama, R., Nomura, K., Morita, A., Watanabe, T., Tanaka, Y., Yazawa, S., & Miwa, T. (2009). Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in capsicum annuum cv. CH-19 sweet. Plant Journal, 59(6), 953-961. https://doi.org/10.1111/j.1365-313X.2009.03921.x
Lebovitz, E. E., Keller, J. M., Kominsky, H., Kaszas, K., Maric, D., & Iadarola, M. J. (2012). Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Molecular Pain, 8, 1-14. https://doi.org/10.1186/1744-8069-8-70
Luo, X. J., Peng, J., & Li, Y. J. (2011). Recent advances in the study on capsaicinoids and capsinoids. European Journal of Pharmacology, 650(1), 1-7. https://doi.org/10.1016/j.ejphar.2010.09.074
Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003). Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical Therapy, 83(8), 713-721. https://doi.org/10.1093/ptj/83.8.713
Mahmmoud, Y. A. (2008). Capsaicin stimulates uncoupled ATP hydrolysis by the sarcoplasmic reticulum calcium pump. Journal of Biological Chemistry, 283(31), 21418-21426. https://doi.org/10.1074/jbc.M803654200
Mannozzi, J., Al-Hassan, M. H., Lessanework, B., Alvarez, A., Senador, D., & O'Leary, D. S. (2021). Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 321(3), R385-R395. https://doi.org/10.1152/ajpregu.00129.2021
Márquez, G., Romero-Arenas, S., Marín-Pagán, C., Vera-Ibañez, A., FernáNdez Del Olmo, M., & Taube, W. (2017). Peripheral and central fatigue after high intensity resistance circuit training. Muscle and Nerve, 56(1), 152-159. https://doi.org/10.1002/mus.25460
Mason, L., Moore, R. A., Derry, S., Edwards, J. E., & McQuay, H. J. (2004). Systematic review of topical capsaicin for the treatment of chronic pain. British Medical Journal, 328(7446), 991-994. https://doi.org/10.1136/bmj.38042.506748.ee
Mata, F., Domínguez, R., López-Samanes, Á., Sánchez-Gómez, Á., Jodra, P., & Sánchez-Oliver, A. J. (2021). Analysis of the consumption of sports supplements in elite fencers according to sex and competitive level. BMC Sports Science, Medicine and Rehabilitation, 13(1), 1-9. https://doi.org/10.1186/s13102-021-00278-0
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., Meeusen, R., van Loon, L. J. C., Shirreffs, S. M., Spriet, L. L., Stuart, M., Vernec, A., Currell, K., Ali, V. M., Budgett, R. G., … Engebretsen, L. (2018). IOC consensus statement: Dietary supplements and the high-performance athlete. British Journal of Sports Medicine, 52(7), 439-455. https://doi.org/10.1136/bjsports-2018-099027
Moseley, A. M., Rahman, P., Wells, G. A., Zadro, J. R., Sherrington, C., Toupin-April, K., & Brosseau, L. (2019). Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions. PLoS ONE, 14(9), 1-16. https://doi.org/10.1371/journal.pone.0222770
Neufer, P. D. (2018). The bioenergetics of exercise. Cold Spring Harbor Perspectives in Medicine, 8(5), 1-11. https://doi.org/10.1101/cshperspect.a029678
Opheim, M. N., & Rankin, J. W. (2012). Effect of capsaicin supplementation on repeated sprinting performance. Journal of Strength and Conditioning Research, 26(2), 319-326. https://doi.org/10.1519/JSC.0b013e3182429ae5
Ota, H., Katanosaka, K., Murase, S., Kashio, M., Tominaga, M., & Mizumura, K. (2013). TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness. PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0065751
Piccolella, S., Crescente, G., Candela, L., & Pacifico, S. (2019). Nutraceutical polyphenols: New analytical challenges and opportunities. Journal of Pharmaceutical and Biomedical Analysis, 175, 112774. https://doi.org/10.1016/j.jpba.2019.07.022
Sanz-Salvador, L., Andrés-Borderia, A., Ferrer-Montiel, A., & Planells-Cases, R. (2012). Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. Journal of Biological Chemistry, 287(23), 19462-19471. https://doi.org/10.1074/jbc.M111.289751
Schmitt, J., & Ferro, A. (2013). Nutraceuticals: Is there good science behind the hype? British Journal of Clinical Pharmacology, 75(3), 585-587. https://doi.org/10.1111/bcp.12061
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., Altman, D. G., Booth, A., Chan, A. W., Chang, S., Clifford, T., Dickersin, K., Egger, M., Gøtzsche, P. C., Grimshaw, J. M., Groves, T., Helfand, M., … Whitlock, E. (2015). Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation. BMJ (Online), 349(January), 1-25. https://doi.org/10.1136/bmj.g7647
Sharma, S. K., Vij, A. S., & Sharma, M. (2013). Mechanisms and clinical uses of capsaicin. European Journal of Pharmacology, 720(1-3), 55-62. https://doi.org/10.1016/j.ejphar.2013.10.053
Taylor, J. L., Amann, M., Duchateau, J., Meeusen, R., & Rice, C. L. (2016). Neural Contributions to Muscle Fatigue. Medicine & Science in Sports & Exercise, 48(11), 2294-2306. https://doi.org/10.1249/mss.0000000000000923
Ulupınar, S., Özbay, S., Gençoğlu, C., Franchini, E., Kishalı, N. F., & İnce, İ. (2021). Effects of sprint distance and repetition number on energy system contributions in soccer players. Journal of Exercise Science and Fitness, 19(3), 182-188. https://doi.org/10.1016/j.jesf.2021.03.003
Urrutia, G., & Bonfill, X. (2010). PRISMA declaration: A proposal to improve the publication of systematic reviews and meta-analyses. Medicina Clínica, 135(11), 507-511. https://doi.org/10.1016/j.medcli.2010.01.015
Vianna, L. C., Fernandes, I. A., Barbosa, T. C., Teixeira, A. L., & Nóbrega, A. C. L. (2018). Capsaicin-based analgesic balm attenuates the skeletal muscle metaboreflex in healthy humans. Journal of Applied Physiology, 125(2), 362-368. https://doi.org/10.1152/japplphysiol.00038.2018
Vriens, J., Appendino, G., & Nilius, B. (2009). Pharmacology of vanilloid transient receptor potential cation channels. Molecular Pharmacology, 75(6), 1262-1279. https://doi.org/10.1124/mol.109.055624
Walter, A. A., Herda, T. J., Ryan, E. D., Costa, P. B., Hoge, K. M., Beck, T. W., Stout, J. R., & Cramer, J. T. (2009). Acute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged men. Journal of the International Society of Sports Nutrition, 6. https://doi.org/10.1186/1550-2783-6-15
Zając, A., Chalimoniuk, M., Gołas̈, A., Lngfort, J., & Maszczyk, A. (2015). Central and peripheral fatigue during resistance exercise - A critical review. Journal of Human Kinetics, 49(1), 159-169. https://doi.org/10.1515/hukin-2015-0118
Zhai, K., Liskova, A., Kubatka, P., & Büsselberg, D. (2020). Calcium entry through trpv1: A potential target for the regulation of proliferation and apoptosis in cancerous and healthy cells. International Journal of Molecular Sciences, 21(11), 1-25. https://doi.org/10.3390/ijms21114177
Zhang, S., Wang, D., Huang, J., Hu, Y., & Xu, Y. (2020). Application of capsaicin as a potential new therapeutic drug in human cancers. Journal of Clinical Pharmacy and Therapeutics, 45(1), 16-28. https://doi.org/10.1111/jcpt.13039
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