Effects of the hydrolyzed collagen supplement Colnatur Sport® on endurance training and performance of runners
Keywords:Collagen, Runners, Training, Supplement, Sport medicine, Nutrition, Health
The main purpose of this observational prospective pilot study was to evaluate the effects of hydrolysed collagen supplementation, in endurance training, in the performance of runners. A cohort of sixty-one subjects (women with an age = 44 ± 5 years; height = 1.65 ± 0.4 m; weight = 58.4 ± 5.2 kg; men with an age = 51 ± 3 years; height = 1.82 ± 0.2 m; weight = 74.4 ± 3.1 kg) received a collagen supplement (11 g / day) during 16 weeks. They performed a 21 kilometre endurance test (21KmET) at baseline and after 16 weeks of follow up. Squat Jump (SJ) and Counter Movement Jump (CMJ) tests were measured before and after each 21KmET and biochemical analyses and a bioimpedance were performed after each 21KmET. Subjects underwent three sport training sessions a week and a supplement intake during the follow up. Regarding the 21KmET time, there were significant differences between before and after supplementation intake (p < .05) and a higher pain perception was assessed with a visual analogue scale at the second 21KmET (p < .05). Significant improvements were observed in handgrip strength, SJ and CMJ after 16 week of supplement intake. Conclusions: A programmed endurance training improves the functionality of the runner in long-distance events and a periodic intake of hydrolysed collagen could help a better performance because it improves the conditions of muscles and joints.
Adam, M., Spacek, P., Hulejová, H., Galiánová, A., & Blahos, J. (1996). Postmenopausal osteopo-rosis. Treatment with calcitonin and a diet rich in collagen proteins. Casopis Lekaru Ceskych, 135(3), 74-78.
Arquer, A., García, M., Laucirica, J. A., Rius, M., Blàvia, M., Fontserè, J., ... & Puig, D. M. (2014). Eficacia y seguridad de un tratamiento oral a base de mucopolisacáridos, colágeno tipo iy vi-tamina C en pacientes con tendinopatías. Apunts. Medicina de l'Esport, 49(182), 31- 36. https://doi.org/10.1016/j.apunts.2013.12.005
Blomstrand, E., Celsing, F., & Newsholme, E. A. (1988). Changes in plasma concentrations of aro-matic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta physiologica Scandinavica, 133(1), 115-121. https://doi.org/10.1111/j.1748-1716.1988.tb08388.x
Borg, G. (1998). Borg's perceived exertion and pain scales. Human Kinetics.
Brown, J. C., Winters-Stone, K., Lee, A., & Schmitz, K. H. (2012). Cancer, physical activity, and exercise. Comprehensive Physiology, 2(4), 2775-2809. https://doi.org/10.1002/cphy.c120005
Carlsohn, A., Cassel, M., Linné, K., & Mayer, F. (2011). How much is too much? A case report of nutritional supplement use of a high-performance athlete. British Journal of Nutrition, 105(12), 1724-1728. https://doi.org/10.1017/S0007114510005556
Cermak, N. M., Res, P. T., De Groot, L. C. P. G. M., Saris, W. H. M., & Van Loon, S. L. (2012). Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis, The American Journal of Clinical Nutrition, 96(6), D1454-1464. https://doi.org/10.3945/ajcn.112.037556
Chakravarty, E. F., Hubert, H. B., Lingala, V. B., & Fries, J. F. (2008). Reduced disability and mor-tality among aging runners: a 21-year longitudinal study. Archives of internal medicine, 168(15), 1638-1646. https://doi.org/10.1001/archinte.168.15.1638
Cheval, B., Sieber, S., Maltagliati, S., Millet, G., Formánek, T., Chalabaev, A., Cullati, S., Boisgontier, M. (2021). Muscle strength is associated with COVID-19 hospitalization in adults 50 years of age or older. MedRxiv : the preprint server for health sciences, 2021.02.02.21250909. https://doi.org/10.1101/2021.02.02.21250909
Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F… Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485-1496. https://doi.org/10.1185/030079908X291967
Clifford, T., Ventress, M., Allerton, D. M., Stansfield, S., Tang, J. C. Y… Stevenson, E. (2019). The effects of collagen peptides on muscle damage, inflammation and bone turnover follow-ing exercise: a randomized, controlled trial. Amino Acids, 51(4), 691-704. https://doi.org/10.1007/s00726-019-02706-5
Dressler, P., Gehring, D., Zdzieblik, D., Oesser, S., Gollhofer, A., & König, D. (2028). Improve-ment of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. J. Sports Sci. Med, 17(2), 298-304.
Figueres Juher, T., & Basés Pérez, E. (2015). Revisión de los efectos beneficiosos de la ingesta de colágeno hidrolizado sobre la salud osteoarticular y el envejecimiento dérmico. Nutrición hospitalaria, 32 Suppl 1, 62-66. https://doi.org/10.3305/nh.2015.32.sup1.9482
Guillerminet, F., Beaupied, H., Fabien-Soulé, V., Tomé, D., Benhamou, C. L…Blais, A. (2010). Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariecto-mized mice: An in vitro and in vivo study, Bone, 46(3), 827-834. https://doi.org/10.1016/j.bone.2009.10.035
Guillerminet, F., Fabien-Soulé, V., Even, P.C., Tomé, D., Benhamou, C. L… Blais, A. (2012). Hydrolyzed collagen improves bone status and prevents bone loss in ovariecto-mized C3H/HeN mice. Osteoporos Int, 23(7), 1909-1919. https://doi.org/10.1007/s00198-011-1788-6
Huang, X., Ma, J., Ying, Y., Liu, K., Jing, C., & Hoa, G. (2021). The handgrip strength and risk of depressive symptoms: a meta-analysis of prospective cohort studies. Quality of Life Re-search: an international journal of quality of life aspects of treatment, care and rehabilitation. Advance online publication. https://doi.org/10.1007/s11136-021-02858-6
Janssen, M., Scheerder, J., Thibaut, E., Brombacher, A., & Vos, S. (2017). Who uses running apps and sports watches? Determinants and consumer profiles of event runners' usage of running-related smartphone applications and sports watches. PloS one, 12(7), e0181167. https://doi.org/10.1371/journal.pone.0181167
Janssen, I., Clarke, A. E., Carson, V., Chaput, J. P., Giangregorio, L. M., Kho, M. E., Poitras, V. J., Ross, R., Saunders, T. J., Ross-White, A., & Chastin, S. (2020). A systematic review of compositional data analysis studies examining associations between sleep, sedentary behav-iour, and physical activity with health outcomes in adults. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 45(10 (Suppl. 2)), S248-S257. https://doi.org/10.1139/apnm-2020-0160
Jendricke, P., Centner, C., Zdzieblik, D., Gollhofer, A., & König, D. (2019). Specific Collagen Pep-tides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients, 11(4), 892. https://doi.org/10.3390/nu11040892
Jendricke, P., Kohl, J., Centner, C., Gollhofer, A., & König, D. (2020). Influence of Specific Colla-gen Peptides and Concurrent Training on Cardiometabolic Parameters and Performance In-dices in Women: A Randomized Controlled Trial. Frontiers in nutrition, 7, 580918. https://doi.org/10.3389/fnut.2020.580918
Khare, S. D., Krco, C. J., Griffiths, M. M., Luthra, H. S., & David, C. S. (1995). Oral administra-tion of an immunodominant human collagen peptide modulates collagen-induced arthritis. J Immunol, 155(7), 3653-3659.
Kirmse, M., Oertzen-Hagemann, V., De Marées, M., Bloch, W., & Platen, P. (2019). Prolonged Col-lagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 11(5), 1-16. https://doi.org/10.3390/nu11051154
Koyama I. (2016). Effects of Collagen Ingestion and their Biological Significance. Journal of Nutri-tion & Food Sciences 6(3): 1000504. https://doi.org/10.4172/2155-9600.1000504
König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A (2018) Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women-a randomized controlled study. Nutrients 10(1):97. https://doi.org/10.3390/nu10010097
Lavie, C. J., Arena, R., Swift, D. L., Johannsen, N. M., Sui, X., Lee, D. C., Earnest, C. P., Church, T. S., O'Keefe, J. H., Milani, R. V., & Blair, S. N. (2015). Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circulation research, 117(2), 207-219. https://doi.org/10.1161/CIRCRESAHA.117.305205
Lavielle-Sotomayor, P., Pineda-Aquino, V., Jáuregui-Jiménez, O., & Castillo-Trejo, M. (2014). Actividad física y sedentarismo: Determinantes sociodemográficos, familiares y su impacto en la salud del adolescente [Physical activity and sedentary lifestyle: family and socio-demographic determinants and their impact on adolescents' health]. Revista de salud publica (Bogota, Colombia), 16(2), 161-172. https://doi.org/10.15446/rsap.v16n2.33329
Maltagliati, S., Sieber, S., Sarrazin, P., Cullati, S., Chalabaev, A., Millet, G. P., Boisgontier, M. P., & Cheval, B. (2021). Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older. MedRxiv : the preprint server for health sciences, 2021.02.25.21252451. https://doi.org/10.1101/2021.02.25.21252451
Margolis, L. M., & Rivas, D. A. (2015). Implications of exercise training and distribution of protein intake on molecular processes regulating skeletal muscle plasticity. Calcified tissue interna-tional, 96(3), 211-221. https://doi.org/10.1007/s00223-014-9921-0
Matsukawa, T., Motojima, H., Sato, Y., Takahashi, S., Villareal, M. O., & Isoda, H. (2017). Upregu-lation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance. Scientific reports, 7, 44799. https://doi.org/10.1038/srep44799
Noh, H. M., & Park, Y. S. (2020). Handgrip strength, dynapenia, and mental health in older Kore-ans. Science and Reports, 10(1), 4004. https://doi.org/10.1038/s41598-020-60835-4
O'Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., & Lavie, C. J. (2014). Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clinic proceedings, 89(3), 382-393. https://doi.org/10.1016/j.mayocp.2013.11.005
Oja, P., Kelly, P., Pedisic, Z., Titze, S., Bauman, A., Foster, C., Hamer, M., Hillsdon, M., & Stama-takis, E. (2017). Associations of specific types of sports and exercise with all-cause and car-diovascular-disease mortality: a cohort study of 80 306 British adults. British journal of sports medicine, 51(10), 812-817. https://doi.org/10.1136/bjsports-2016-096822
Pilegaard, H., & Richter, E. A. (2008). PGC-1alpha: important for exercise performance?. Journal of applied physiology (Bethesda, Md. : 1985), 104(5), 1264-1265. https://doi.org/10.1152/japplphysiol.90346.2008
Rasmussen, C.; Greenwood, M.; Kalman, D.; Antonio, J. Nutritional Supplements for Endurance Athletes. In Nutritional Supplements in Sports and Exercise; Humana Press: Totowa, NJ, USA, 2008; pp. 369-407. https://doi.org/10.1007/978-1-59745-231-1_11
Shaw, G., Lee-Barthel, A., Ross, M. L., Wang, B., & Baar, K. (2017). Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. The American journal of clinical nutrition, 105(1), 136-143. https://doi.org/10.3945/ajcn.116.138594
Soenen, S., Plasqui, G., Smeets, A. J., & Westerterp-Plantenga, M. S. (2010). Protein intake induced an increase in exercise stimulated fat oxidation during stable body weight. Physiology & be-havior, 101(5), 770-774. https://doi.org/10.1016/j.physbeh.2010.08.019
Takeda, S., Park, J. H., Kawashima, E., Ezawa, I., & Omi, N. (2013). Hydrolyzed collagen intake increases bone mass of growing rats trained with running exercise. Journal of the Interna-tional Society Sports Nutrition. 10(35), 1-9. https://doi.org/10.1186/1550-2783-10-35
Tremblay, M. S., LeBlanc, A. G., Kho, M. E., Saunders, T. J., Larouche, R., Colley, R. C., ... Con-nor Gorber, S. (2011). Systematic review of sedentary behaviour and health indicators in school-aged children and youth. The International Journal of Behavioral Nutrition and Phys-ical Activity, 8, 98. https://doi.org/10.1186/1479-5868-8-98
Williams P. T. (2011). Exercise attenuates the association of body weight with diet in 106,737 run-ners. Medicine and science in sports and exercise, 43(11), 2120-2126. https://doi.org/10.1249/MSS.0b013e31821cd128
Woo, T., Lau, L., Cheng, N., Chan, P., Tan, K., & Gardner, A. (2017). Efficacy of oral collagen in joint pain-osteoarthritis and rheumatoid arthritis. Journal of Arthritis, 6(2), 1-4.
Zdzieblik, D., Oesser, S., Baumstark, M., Gollhofer, A., & König, D. (2015). Collagen peptide sup-plementation in combination with resistance training improves body composition and in-creases muscle strength in elderly sarcopenic men: A randomised controlled trial. British Journal of Nutrition,114(8), 1237-1245. https://doi.org/10.1017/S0007114515002810
Zdzieblik, D., Oesser, S., Gollhofer, A., & König, D. (2017). Improvement of activity-related knee joing discomfort following supplementation of specific collagen peptides. Applied physiolo-gy, nutrition, and metabolism, 42(6), 588-595. https://doi.org/10.1139/apnm-2016-0390
Zdzieblik D, Brame J, Oesser S, Gollhofer A, & König D. (2021).The Influence of Specific Bioac-tive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients. 2021;13(2):523. https://doi.org/10.3390/nu13020523
How to Cite
Each author warrants that his or her submission to the Work is original and that he or she has full power to enter into this agreement. Neither this Work nor a similar work has been published elsewhere in any language nor shall be submitted for publication elsewhere while under consideration by JHSE. Each author also accepts that the JHSE will not be held legally responsible for any claims of compensation.
Authors wishing to include figures or text passages that have already been published elsewhere are required to obtain permission from the copyright holder(s) and to include evidence that such permission has been granted when submitting their papers. Any material received without such evidence will be assumed to originate from the authors.
Please include at the end of the acknowledgements a declaration that the experiments comply with the current laws of the country in which they were performed. The editors reserve the right to reject manuscripts that do not comply with the abovementioned requirements. The author(s) will be held responsible for false statements or failure to fulfill the above-mentioned requirements.
This title is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND 4.0).
You are free to share, copy and redistribute the material in any medium or format. The licensor cannot revoke these freedoms as long as you follow the license terms under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
Transfer of Copyright
In consideration of JHSE’s publication of the Work, the authors hereby transfer, assign, and otherwise convey all copyright ownership worldwide, in all languages, and in all forms of media now or hereafter known, including electronic media such as CD-ROM, Internet, and Intranet, to JHSE. If JHSE should decide for any reason not to publish an author’s submission to the Work, JHSE shall give prompt notice of its decision to the corresponding author, this agreement shall terminate, and neither the author nor JHSE shall be under any further liability or obligation.
Each author certifies that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article, except as disclosed on a separate attachment. All funding sources supporting the Work and all institutional or corporate affiliations of the authors are acknowledged in a footnote in the Work.
Each author certifies that his or her institution has approved the protocol for any investigation involving humans or animals and that all experimentation was conducted in conformity with ethical and humane principles of research.
Biomedical journals typically require authors and reviewers to declare if they have any competing interests with regard to their research.
JHSE require authors to agree to Copyright Notice as part of the submission process.